Seminar: Steve Ziegler

MBIM Seminar Series

Starts

Dec 02, 2025 - 12:30 pmAdd to Calendar 2025-12-02 20:30:00 2025-12-02 20:30:00 Seminar: Steve Ziegler Seminar: Regulation of Regulatory T cell Function by Foxp3 Isoforms Abstract: Regulatory T cells (Tregs) function to maintain immune homestasis through a variety of mechanisms. Tregs are defined by the expression of the transcriptional regulatory FOXP3, which in humans is expressed by 2 FOXP3 isoforms. We have found a novel mechanism of Treg-mediated immune suppression involving regulating protein translation, and have developed models to study the function in individual FOXP3 isoforms. LSC 3 (Life Sciences Institute - 2350 Health Sciences Mall) MBIM itsupport@microbiology.ubc.ca America/Vancouver public

Ends

Dec 02, 2025 - 1:30 pm

Location

LSC 3 (Life Sciences Institute - 2350 Health Sciences Mall)

Hosted by

Phil Domeier

Presenter title

Member, Center for Fundamental Immunology, Benaroya Research Institute

Presenter name

Steve Ziegler

Seminar: Regulation of Regulatory T cell Function by Foxp3 Isoforms

Abstract: Regulatory T cells (Tregs) function to maintain immune homestasis through a variety of mechanisms. Tregs are defined by the expression of the transcriptional regulatory FOXP3, which in humans is expressed by 2 FOXP3 isoforms. We have found a novel mechanism of Treg-mediated immune suppression involving regulating protein translation, and have developed models to study the function in individual FOXP3 isoforms.